The substantia nigra cells produce dopamine, and their loss is like a slow, cruel drought for the brain's movement signals. Early on, the tremor starts—just a small leak in the system. By late stages, that drought has parched the pathways for smooth motion, leaving rigidity and freezing. In my lab, we're trying to engineer neuroprotective peptides, but watching Papa's hands shake while he adjusts that old transistor reminds me we're not just patching pipes; we're trying to save the whole well.
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