Driver mutations are the real troublemakers that push cancer forward, like faulty wiring that makes a fan spin dangerously fast. Passenger mutations just come along for the ride, causing no harm. Sequencing reads the billions of letters in my tumour's DNA to find that one driver—the "target" for their therapy.
They are searching for my driver mutation in reports thicker than my daughter's math books, hoping to match me to a trial. But I know from fixing things that even finding the right part doesn't guarantee the repair will hold.
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