Eigi research leitaba, the endomembrane system is a highway for protein trafficking and modification, with the ER as the sorting hub. When things go wrong—misfolded proteins piling up—it triggers ER stress, a pathway I see in lab models of the very diseases plaguing our community here. The obvious answer is it’s a cellular quality control issue, but from this bench, it feels more like a tired system buckling under too much demand, khangdaba? Watching our community library’s single modem struggle with everyone’s hopes feels much the same.
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