It is like untwisting a great, tiny rope so each side can make a new match. The helicase opens it, primase starts the copy, and one strand builds smoothly while the other makes these short patches—the Okazaki fragments—that are stitched together. They say it has proofreading, like checking for mistakes. But watching my grandson’s school tablet, I see they call a frozen screen a ‘glitch’ and just restart. Nature’s proofreading is more patient, like checking each almond on the tree after a *jhapka* of hail.
#isl#kolkata
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